Hello, I'm Jenny Lytle.

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Advanced SIG-1273

Concentrated Serum

Size: 1 fl.oz.

Get that GLOW in a snap. Outsmart aging and supercharge your skincare results with Advanced SIG-1273 Concentrated Serum—formulated with 5X the active concentration of our patented age-fighting molecule SIG-1273 for visible results—faster. This powerhouse serum covers all your bases, delivering a naturally radiant glow, and firmer and more luminous skin within days—with results that build over time.

What does 1273 mean? It’s significant, actually—it represents the number of iterations our scientists tried before they found the perfect formulation. Binding with skin at the cellular level, this anti-aging heavy hitter protects against collagen loss over time (which happens naturally as we age), while providing increased levels of antioxidants to reduce the appearance of fine lines and wrinkles. Science in every drop, for radiant results.

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$180
$135
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About Smartshop

Bring on the Perks, Please!

Here are some perks of having a SmartShop Order and being a Preferred Customer.

  • Icon of a wrapped gift box with sparkles surrounding it.

    Birthday Club

    A FREE Birthday Gift with SmartShop Order

  • Icon of a microphone with stars

    Give $10, Get $10

    Earn $10 NeoraCASH for every Preferred Customer referral

  • Money icon represents Special Savings with Preferred Customer Perks.

    Special Savings

    Save up to 25% on retail price with every scheduled delivery

  • Star and structure icon represents Exclusive Access to Limited Edition Collection with Preferred Customer Perks.

    Exclusive

    Preferred Customers get exclusive access to limited-edition collections

  • Piggy Bank and money stack icon represents 10% Neora Cashback on every purchase with Preferred Customer Perks.

    10% in NeoraCASH

    Earn NeoraCASH with every SmartShop (Monthly Delivery) order to use for a future purchase

  • Delivery truck icon represents Free Shipping with Preferred Customer Perks.

    Free Shipping

    Get free shipping on all orders of $150 or more

$180
One-Time Purchase (Single Delivery)
Retail Price

30-Day Money-Back Guarantee

Add To Bag

Real People. Real Results.

See how Neora customers have transformed with Advanced SIG-1273 Concentrated Serum.

1 - Before and After Real Results photo of a woman's face.
2 - Before and After Real Results photo of a woman's face.
3 - Before and After Real Results photo of a woman's face.
4 - Before and After Real Results photo of a woman's face.
5 - Before and After Real Results photo of a woman's face.
6 - Before and After Real Results photo of a woman's face.
7 - Before and After Real Results photo of a woman's face.
8 - Before and After Real Results photo of a woman's face.

Why We Love It.

  • Icon of a checkmark

    Promotes healthy skin

    at the cellular level

  • Icon of a checkmark

    Decreases the appearance

    of redness

  • Icon of a checkmark

    Designed to optimize

    the skin’s two main functions: hydration and protection, for brighter, clearer and healthier skin

  • Icon of a checkmark

    Improves overall

    skin health

  • Icon of a checkmark

    Minimizes pore size

  • Icon of a checkmark

    Protects against

    collagen loss over time

  • Icon of a checkmark

    Hydrates skin

    for a naturally radiant glow

  • Icon of a checkmark

    Reduces the appearance

    of fine lines and wrinkles

  • Icon of a checkmark

    Perfect for

    when your skin needs a “refresh” button

All the Good Stuff.

  • Drawing of molecules

    SIG-1273®

    SIG-1273® is a patented, exclusive dual-action molecule that acts as an antioxidant and skin protectant and helps support the skin's ability to combat the oxidative stress that can lead to fine lines and wrinkles.

  • Drawing of hyaluronic acid at a molecule level

    Hyaluronic Acid (as Sodium Hyaluronate)

    A naturally occurring molecule in the skin that improves skin moisture and helps strengthen the skin's protective barrier.*

  • Drawing of a glycerin droplet.

    Glycerin

    Derived from lipids, this skin humectant absorbs moisture and supports skin's natural barrier.

  • Drawing of molecules

    SIG-1273®

    SIG-1273® is a patented, exclusive dual-action molecule that acts as an antioxidant and skin protectant and helps support the skin's ability to combat the oxidative stress that can lead to fine lines and wrinkles.

  • Drawing of hyaluronic acid at a molecule level

    Hyaluronic Acid (as Sodium Hyaluronate)

    A naturally occurring molecule in the skin that improves skin moisture and helps strengthen the skin's protective barrier.*

  • Drawing of a glycerin droplet.

    Glycerin

    Derived from lipids, this skin humectant absorbs moisture and supports skin's natural barrier.

See Full Ingredients ❯ ❮ View Less

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid.

None of the Bad.

Clean Formula Guarantee.

  • A green stamp with the words "Neora Clean."

    Clean Formula

  • Drawing of a checkmark award ribbon that all Neora products have patented ingredients.

    Patented Ingredients

  • Drawing that represents Paraben compound that all Neora products are free from.

    Vegan

  • Drawing of a rabbit.

    Cruelty Free

  • Drawing that represents glutter that all Neora products are free from.

    Gluten Free

  • Drawing that represents Paraben compound that all Neora products are free from.

    Paraben Free

  • Drawing that represents Phthalate that all Neora products are free from.

    Phthalate Free

  • Drawing that represents Propylene Glycol that all Neora products are free from.

    Propylene Glycol Free

  • Drawing of a spray bottle that represents that all Neora products are free from Synthetic Fragrances and Colors.

    No Synthetic Colors

  • Drawing of an icon that represents that all Neora products are Dermatologist tested.

    Dermatologist Tested

  • Drawing of an icon that represents that all Neora products are Non-Comedogenic.

    Non Comedogenic

  • Drawing of an profile of a woman with her hair up that represents that all Neora products are suitable for all skin types.

    All Skin Types

How To Use:

Advanced SIG-1273 Concentrated Serum
  • Step 1: Apply 1-2 pumps to clean, dry skin.
  • Step 2: May apply moisturizer over serum or mix with it for best results.
  • Pro Tip: Apply moisturizer over serum or mix with it for best results.
Thumbnail of the SIG-1723 Advanced Serum How-to video.
Pro Tip: Advanced SIG-1273 Concentrated Serum also works great with:
  • Age IQ® Night Cream

    One Time: $120 Retail Value

    SmartShop: $95

    View Details
  • Age IQ® Day Cream

    One Time: $100 Retail Value

    SmartShop: $80

    View Details
  • Age IQ® Eye Serum

    One Time: $80 Retail Value

    SmartShop: $65

    View Details

Bring on the Perks, Please!

Here are some perks of having a SmartShop Order and being a Preferred Customer.

Shop Smart
  • Icon of a wrapped gift box with sparkles surrounding it.
    Birthday Club

    A FREE Birthday Gift with SmartShop Order

  • Icon of a microphone with stars
    Give $10, Get $10

    Earn $10 NeoraCASH for every Preferred Customer referral

  • Money icon represents Special Savings with Preferred Customer Perks.
    Special Savings

    Save up to 25% on retail price with every scheduled delivery

  • Star and structure icon represents Exclusive Access to Limited Edition Collection with Preferred Customer Perks.
    Exclusive

    Preferred Customers get exclusive access to limited-edition collections

  • Piggy Bank and money stack icon represents 10% Neora Cashback on every purchase with Preferred Customer Perks.
    10% in NeoraCASH

    Earn NeoraCASH with every SmartShop (Monthly Delivery) order to use for a future purchase

  • Delivery truck icon represents Free Shipping with Preferred Customer Perks.
    Free Shipping

    Get free shipping on all orders of $150 or more